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KMID : 1138520130160010037
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Journal of Pharmacopuncture
2013 Volume.16 No. 1 p.37 ~ p.42
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Effect of Geumgoeshingi-Whan Pharmacopuncture on the Blood Pressure in Spontaneously Hypertensive Rats
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Lee Mee-Sun
Lee Sang-Mi
Jeong Ho-Hyn
Park Man-Yong
Kim Dong-Woung
Song Bong-Keun
Lee Jong-Deok
Lee Ho-Sub
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Abstract
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Objective: The aim of this experiment was to investigate the effect and the mechanism of Geumgoeshingi-whan (GGSGW) Pharmacopuncture at the acupoint GV 4 on the blood pressure in spontaneously hypertensive rats (SHR).
Methods: SHR were injected with normal saline solution (Control-SHR group)or GGSGW Pharmacopuncture (GGSGW-SHR group) at the acupoint GV 4. The systolic arterial blood pressure and renal parameters were measured for two weeks.
Results: The systolic arterial blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR, followed by a significant rise in creatine clearance. The plasma levels of aldosterone were decreased significantly after GGSGW Pharmacopunctureas were the plasma levels of atrial natriuretic peptide (ANP).
Conclusion: These results suggest that the blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR and that the depressor response of the blood pressure was related to decreases in the plasma levels of aldosterone and ANP.
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KEYWORD
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Geumgoeshingi-whan, Pharmacopuncture, SHR, hypertension, ANP, Renal function
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